1 edition of Contact hypersensitivity in experimental animals. found in the catalog.
Contact hypersensitivity in experimental animals.
|Statement||Editors: Darien Parker and J. L. Turk.|
|Series||Monographs in allergy,, v. 8, Monographs in allergy ;, vol. 8.|
|Contributions||Parker, Darien, ed., Turk, J. L., ed., Frey, Johann R.|
|LC Classifications||QR188 .C66|
|The Physical Object|
|Pagination||xiv, 182 p.|
|Number of Pages||182|
|LC Control Number||74180282|
Murine contact hypersensitivity (CHS) is widely used as a model for allergic contact dermatitis (ACD). One of the most common diseases caused by repeated skin exposure to contact allergens, ACD is classified as a type IV or a delayed type hypersensitivity reaction. After the inoculation of the Enders strain of mumps virus into the anterior chamber of the eye of guineapigs, and also intranasally, the animals developed corneal opacity, miosis and exophthalmos; the changes attained a maximum after hours and passed off after days. Inhibiting antibody appeared after 72 hours and attained a titre of after 3 weeks.
Hypersensitivity responses are commonly categorized in four groups (Type I, Type II, Type III, and Type IV) later the proposal of Gell and Coombs in Discover the world's research 17+ million. meters in animals under experimental conditions. Restraint Restraint is described as immobilization of an animal by keeping it or parts of it, in a comfortable but safe hold by hand or by means of a physical device. Physical restraint is performed on conscious animals undergo-ing manipulations, which do not require sedation or.
Using the fluorescent antibody technique we here demonstrate that fibrin deposition is a prominent and consistent feature of both allergic contact dermatitis and classic delayed hypersensitivity skin reactions in man. Fib was detected in 55 of 58 delayed reactions studied at the peak of their intensity. Examples of this T H 1-mediated hypersensitivity are observed in tuberculin the Mantoux skin test and contact dermatitis, such as occurs in latex allergy reactions. In the second type IV subcategory, CD4 T H 2-mediated reactions result in chronic asthma or chronic allergic rhinitis. In these cases, the soluble antigen is first inhaled.
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Genre/Form: Congress: Additional Physical Format: Online version: Contact hypersensitivity in experimental animals. Basel, New York, S. Karger, REFERENCES Andersen K. () Testing for contact allergy in experimental animals. Pharmacology and Toxicol Basketter D.
A., Selbie E., Scholes E. W., Lees D., Kimber I. and Botham P. () Results with OECD recommended positive control sensitizers in the maximization, Buehler and local lymph node by: 2. Abstract. Contact hypersensitivity has been studied extensively in man and experimental animals.
It represents one particular type of delayed-type hypersensitivity and was thought to provide a simple model of this type of : G. Stingl, W. Aberer. Contact hypersensitivity J Exp Med () G.B. Toews, P.R. Bergstresser, J.W.
Streilein, S. Sullivan, Epidermal Langerhaus cell density determines whether contact hypersensitivity or unresponsiveness follows painting with DNFB J Immunol () Cited by: Allergic contact dermatitis is a rare hypersensitivity disorder in the dog. Clinical diagnosis is not easy. Primary lesions are transient.
Secondary lesions caused by chronic inflammation and self. Experimental studies from the last 10 years have demonstrated that, in normal contact hypersensitivity responses to strong haptens, CD8(+) type 1 T-cells are effector cells of contact.
This study indicates that clonidine-TTS suppressed the elicitation of contact hypersensitivity reactions. The observed immunosuppressive effect of clonidine may account for the relatively weak hypersensitivity reactions to this drug in experimental animal studies. Induction of experimental contact hypersensitivity in mouse ear.
For the induction of contact hypersensitivity (CHS), mice were divided into 3 groups with 5 mice per each treatment group; normal healthy control treated with PBS alone without CHS induction, treatment groups treated either with vacant gel or gel containing placenta extract.
Contact hypersensitivity response to TNCB in BALB/c mice. BALB/c mice on a HFD and a ND for 4 weeks were sensitized with 1% TNCB (25 μL in acetone) on their shaved abdomen.
Seven days later, mice were challenged with 10 μL of % (A) and % (B) of TNCB solution in acetone to both sides of the ear pinnae to induce a contact hypersensitivity. Introduction. Allergic contact dermatitis is a common skin disease that is caused by type IV delayed type hypersensitivity responses to antigens that come in contact with the skin ic contact dermatitis is a major cause of occupational skin disease, and accounts for approximately 20% of all work-related health complaints.
Contact hypersensitivity (CHS) responses require the participation of T cells, along with a variety of cytokines and adhesion molecules.
In the classical CHS, antigen-specific T cells are recruited to a site of antigenic challenge, where they react with antigen, release cytokines, and attract other inflammatory cells.
Definitions. Hypersensitivity reaction: a condition in which the normally protective immune system has a harmful effect on the body; Allergy: an abnormal immunological response to an otherwise harmless environmental stimulus (e.g., food, pollen, animal dander); Autoimmune disease: an abnormal immunological response directed against an antigen that is actually part of the body itself.
Many forms of delayed-onset, lymphocyte-mediated hypersensitivity reactions in animals and man are characterized by an extensive infiltration of basophilic leukocytes [1–6].
We have designated such reactions by the descriptive term “cutaneous basophil hypersensitivity” (CBH) to distinguish them from classic delayed hypersensitivity (DH). Cutaneous basophil hypersensitivity, an immune inflammatory reaction characterized by infiltrates of basophils and a delayed time-course, was studied in guinea pigs contact sensitized with oxazolone.
Routine histological techniques, employing ordinary paraffin sections, were modified to. Allergic contact dermatitis (ACD) caused by reactive haptens and metal ions, a form of delayed type hypersensitivity, is one of the most common skin diseases (1, 2).Contact hypersensitivity (CHS), the recognized mouse model for studying human ACD, involves painting a small area of abdominal skin with the allergen (sensitization), e.g., 2,4,6-trinitrochlorobenzene (TNCB), followed by an.
Contact hypersensitivity is part of the adaptive immune response and a form of delayed-type hypersensitivity (DTH) or cell-mediated immune reaction that is expressed in the epidermis. It is the most frequent form of DTH reaction and the most prominent clinical manifestation of a.
Contact hypersensitivity testing is typically performed either in mice or in guinea pigs and is directly derived from classical models used for the detection of contact sensitizing chemicals.
Whatever the selected model, it is comprised of a sensitizing phase where the animals are applied a strong contact sensitizer topically, then a rest phase.
experimental hypersensitivity in the rabbit: e ffect of i nhibition of a ntibody f ormation by x-r adiation and n itrogen m ustards on the h istologic and s erologic s equences, and on the b ehavior of s erum c omplement, f ollowing s ingle l arge i njections of f oreign p roteins.
Search the world's most comprehensive index of full-text books. My library. An analysis of allergic contact dermatitis - a common occupational health problem affecting between % of the workforce.
This book considers the condition from the perspective of the toxicologist rather than the dermatologist. Allergic contact dermatitis (ACD) is one of the most prevalent skin diseases consisting of sensitization and elicitation phases 1,ed studies of hapten-induced contact hypersensitivity (CHS) as a murine model of ACD have expanded our understanding of the mechanism of allergic reactions occurring in the skin, especially the specific roles of a variety of immune cells.Experimental animals A total of 72 female Balb/c mice (6–8 weeks; 17± g) were purchased from the Guangdong Medical Laboratory Animal Center (Guangdong, China).
The animals were housed at 24°C with 40–60% humidity on a h dark/light cycle, and provided with food and water ad libitum.Examples of this T H 1-mediated hypersensitivity are observed in tuberculin the Mantoux skin test and contact dermatitis, such as occurs in latex allergy reactions.
In the second type IV subcategory, CD4 T H 2-mediated reactions result in chronic asthma or chronic allergic rhinitis.